NMR Spectroscopy

The School has a long-standing and evolving commitment to the application of high field NMR spectroscopy to the study of biomolecular structure, analyte identification and quantification in tissues and fluids, in the kinetics of membrane transport and metabolism, and in molecular diffusion. Concomitant with the applications has been the implementation and design of novel NMR procedures for the study of biological systems including magnetic field and diffusion theory relating to cells and the development of new radio-frequency pulse sequences.

The School houses a Bruker Avance III 400 wide-bore NMR spectrometer equipped with a mini 0.5 micro-imaging system for small animals, a high field gradient (1000 G/cm) diffusion probe, a Doty variable angle spinning probe and several high resolution probes. It also houses a Bruker Avance III 600 and 800 narrow-bore NMR both with TCI cryogenic probeheads that are used for protein/nucleic acids structural. A CH dual cryogenic probehead is available on the 600 for high-sensitivity metabolism work. In addition, we have a Bruker Minispec low resolution spectrometer primarily for educational use.

Researchers in this field